By Kyle J. Norton
Cardiovascular diseases (CVD) are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.
According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015 were in men, comapred to women.
In other words, narrowing the arteries due to plaques accumulation is a major cause of heart disease and stroke.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.
Most common symptoms found in patients with antiatherosclerosis are involved in the reduce blood flow to the body, including chest pain or angina, pain in the leg, and arm, shortness of breath and fatigue and confusion.
According to Dr. Roma Pahwa and colleagues, atherosclerosis cause approximately 50% of all deaths in westernized society associated with the inflammation in the arteries involved in the accumulation of cholesterol in the bloodstream.
Epidemiologically, the most common risk factors of atherosclerosis are unhealthy blood cholesterol levels associated with high levels of bad and low levels of good cholesterol, high blood pressure, smoking, insulin resistance, diabetes, overweight or obesity, physical inactivity.
Some researchers suggested that the promotion of a high-fat diet that induces widespread obesity in the Western world may be one of the major culprits that cause atherosclerosis.
Dr. Lovren F and colleagues wrote, “Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases”.
And, ” A plethora of mechanisms, including abnormalities in lipid metabolism, insulin resistance, inflammation, endothelial dysfunction, adipokine imbalance, and inflammasome activation have been suggested to underlie the relationship between obesity and atherosclerosis.”.
On findings a potential compound for the treatment of multiple sclerosis (MS), researchers examined the efficacy of supplementation with curcumin on reducing intestinal cholesterol absorption in animal models.
The study included high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice prevented atherosclerosis fed a high-fat diet supplemented with or without curcumin (0.1% w/w) for 16 weeks.
Based on the tested differentiation, the curcumin treatment group showed not only a reduced cholesterol accumulation in the aortas by 56% but also lowered plasma total cholesterol and low-density lipoprotein cholesterol levels comapred to the non-curcumin group.
Furthermore, curcumin supplementation group also demonstrated a reduced risk of atherosclerotic lesions by 45%.
Moreover, the efficacy of the anti antiatherogenic effect of curcumin was associated with a significant decrease in intestinal cholesterol absorption by 51% by inhibiting the intestinal gene expression of Niemann-Pick C1-like 1 involved in cholesterol uptakes.
Collectively, researchers said, “These findings support the hypothesis that curcumin supplementation reduces intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed ApoE-/- mice”.
And ” Curcumin affords a potent antiatherogenic action by inhibiting intestinal cholesterol absorption in the mouse”.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy by Momtazi-Borojeni AA1,2, Abdollahi E3,4, Nikfar B5, Chaichian S6,7, Ekhlasi-Hundrieser M. (PubMed)
(2) Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice by Zou J1, Zhang S2, Li P2, Zheng X2, Feng D. (PubMed)
(3) Atherosclerosis by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(4) Obesity and atherosclerosis: mechanistic insights by Lovren F1, Teoh H2, Verma S. (PMC)