By Kyle J. Norton
Nephrotoxicity is toxicity in the kidneys associated with reduced function of the kidney due to toxic chemicals, and medications.
The kidneys are essential bean shape organ of our body, located just below the rib cage, one on each side of your spine.
The heart, a four-chambered, hollow muscle and double acting pump that is located in the chest between the lungs is a muscular organ in the human body processed the function that pumps blood through the blood vessels of the circulatory system to nourish the body and assist in the removal of metabolic wastes.
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
On finding a potential compound which processes cardio and nephroprotective effects, researchers examined the effects of lycopene against the toxic effects of Aflatoxin B1(AFB1) exposure in kidney and heart of experimental rats.
A total of 42 healthy three-month-old male Wistar-Albino rats were randomly divided into six experimental groups including 7 rats in each as following control group, lycopene (5 mg/kg/day, orally for 15 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) group, AFB1 (1.5 mg/kg/day, orally for 3 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) + lycopene (5 mg/kg/day, orally for 15 days) group and AFB1(1.5 mg/kg/day, orally for 3 days) + lycopene (5 mg/kg/day, orally for 15 days) group.
Compared to AFB1 and according to the tested analysis, the elevated levels of malondialdehyde (MDA) levels associated with oxidative stress markers were significantly decreased in the lycopene treatment group.
The reduced levels of antioxidant enzymes in the AFB1 group such as glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glucose-6-phosphate-dehydrogenase (G6PD) activities were increased substantially in kidney and heart tissues upon the injection of lycopene.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment by Anjos Ferreira AL1, Russell RM, Rocha N, Placido Ladeira MS, Favero Salvadori DM, Oliveira Nascimento MC, Matsui M, Carvalho FA, Tang G, Matsubara LS, Matsubara BB. (PubMed)