By Kyle J. Norton
Dejerine-Sottas disease is an inherited neurological disorder that causes the enlarged or thickened peripheral nerves, leading to muscle weakness.
With an aim to find a potential compound for the treatment of Charcot-Marie-Tooth disease type 1B caused by mutations in myelin protein zero, researchers examined the effect of turmeric on an animal model.
The study included R98C mice, an authentic model induced the early onset Charcot-Marie-Tooth disease type 1B, in the developing neuropathy.
According to the tested assays, R98C mutant mice were treated with curcumin dissolved in sesame oil or phosphatidylcholine curcumin, starting at 4 days of age showed an increased numbers of large-diameter axons in their sciatic nerve.
Based on the findings, researchers wrote, “these data demonstrate that treatment with curcumin dissolved in sesame oil or phosphatidylcholine curcumin improves the peripheral neuropathy of R98C mice by alleviating endoplasmic reticulum stress, by reducing the activation of unfolded protein response and by promoting Schwann cell differentiation”.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice by Patzkó A1, Bai Y, Saporta MA, Katona I, Wu X, Vizzuso D, Feltri ML, Wang S, Dillon LM, Kamholz J, Kirschner D, Sarkar FH, Wrabetz L, Shy ME. (PubMed)