Cardiac hypertrophy (CH) is a medical condition characterized by the abnormal enlargement or thickening of the heart muscle, affecting the heart function in pumping blood.
Cardiac hypertrophy induced reduced blood flow to the body may cause symptoms of shortness of breath, chest pain, particularly during exercise.
*Ventricular hypertrophy due to intense sports activities, particularly in people with intensive exercise
* Ventricular hypertrophy due to hypertension-induced ventricular pressure overload.
* Ventricular hypertrophy due to tricuspid regurgitation induced ventricular volume overload.
Dr. Joa˜o Carlos Hueb, the lead scientist in the article “Association Between Atherosclerotic Aortic Plaques and Left Ventricular Hypertrophy in Patients With Cerebrovascular Events” wrote, “Almost half of the patients (43.1%) presented atherosclerotic lesions in the aorta. LVH was present in 90.0% of patients with a plaque and in only 30.3% of patients without plaque. Using high blood pressure as a covariate, the risk of patients with LVH presenting atherosclerotic plaque in the aorta was 18.23-fold greater than the risk for patients without LVH (95% CI, 5.68 to 58.54; P0.0001)”
In the urgency to find a natural treatment that processes anti-cardiac hypertrophy associated with the prevalence of heart failure, researchers evaluated the anti-hypertrophy and anti-fibrosis potential of a natural plant triterpenoid, Cucurbitacin B in vivo.
The study included mice induced cardiac hypertrophy by aortic banding (AB) received cucurbitacin B treatment (Gavage, 0.2 mg/kg body weight/2 day) after 1 week of surgery.
Observation after 4 weeks of AB, cucurbitacin B (CuB) demonstrated a strong anti-hypertrophy and -fibrosis ability by decreasing heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.
Furthermore, CuB also protected the heart by ameliorating systolic and diastolic abnormalities, normalized the gene expression of hypertrophic and fibrotic markers induced by aortic banding (AB).
Moreover, cucurbitacin B also showed significant hypertrophy inhibitory effect in phenylephrine that stimulates cardiac muscle cells.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Xiao Y1,2,3, Yang Z1,2,3, Wu QQ1,2,3, Jiang XH1,2,3, Yuan Y1,2,3, Chang W1,2,3, Bian ZY1,2,3, Zhu JX1,2,3, Tang QZ. (PubMed)
(2) Association Between Atherosclerotic Aortic Plaques and Left Ventricular Hypertrophy in Patients With Cerebrovascular Events” by Joa˜o Carlos Hueb, MD, PhD; Silme´ia G. Zanati, MD; Katashi Okoshi, MD, PhD; Ce´sar N. Raffin, MD, PhD; Liciana Vaz de Arruda Silveira, PhD; Beatriz B. Matsubara, MD, PhD. (AHA journals)