Obesity is a chronic and medical condition associated with excessive fat accumulation over time.
According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obese.
In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.
Today, the widespread obesity in the US population have caused a significant economic impact on the U.S. health care system, including direct and indirect costs.
In the concern of the rise of obese incidence in the world, researchers examined the phytotherapeutic protein stem bromelain (SBM) anti-obesity activity.
In the cellular levels, SBM irreversibly inhibited 3T3-L1 adipocyte differentiation in the expression of the obese gene product (leptin) in white adipose and induced apoptosis and lipolysis in mature adipocytes.
At the molecular level, SBM suppressed adipogenesis by inhibiting gene expression of PPARγ in developing obesity.
Furthermore, SBM also reduced the secretion of adipocyte fatty acid-binding protein (ap2) associated with obese glucose and lipid metabolism and fatty acid synthase (FAS) involved food intake and body weight.
Lipoprotein lipase (LPL) which leads to increased lipid partitioning to other tissues, insulin resistance, and obesity and gene CD36 CD36 associated with a number of metabolic pathways with relevance to obesity and enzyme acetyl-CoA carboxylase (ACC) involved the biosynthesis and metabolism of fatty acids also inhibited by the injection of SBM.
Moreover, SBM was found to augment the expression of TNFα(tumor necrosis factor alpha) -induced lipolysis and apoptosis in mature adipocytes, another indication of anti-obesity properties.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Inhibition of adipogenesis and induction of apoptosis and lipolysis by stem bromelain in 3T3-L1 adipocytes by Dave S1, Kaur NJ, Nanduri R, Dkhar HK, Kumar A, Gupta P. (PubMed)
(2) Plant proteases for bioactive peptides release: A review by Mazorra-Manzano MA1, Ramírez-Suarez JC2, Yada RY. (PubMed)
(3) The economic burden of obesity and diabetes by November 6, 2018, by Jennifer Calihan. (Diet Doctor)